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Further information

Full list of projects

Scalable economic DNA synthesis by oligoseed amplification with novel DNA polymerase enzymes

Project lead: Nunabio Limited

Theme: biomedicine

UNIVERCell: an engineered red blood cell line to unlock a new, universal therapeutic modality

Project lead: Scarlet therapeutics limited

Theme: biomedicine

A heterologous expression toolkit for large-scale production of novel antimicrobials from diverse microbes

Project lead: Bactobio Limited

Theme: crossing cutting tools and services

Engineering a microbial platform for the sustainable production of paclitaxel

Project lead: 17CICADA LTD

Theme: biomedicine

Engineered signal peptides to enhance expression levels in cell and gene therapies

Project lead: Syngensys Limited

Theme: biomedicine

Continuous oscillating baffled reactor-with-biocatalysts-for accelerated-reactions (COBRA)

Project lead: Impact Laboratories Limited

Theme: environmental solutions

The first fully biobased and biodegradable textile coating delivered from scalable engineered bacteria extracts to support affordable sustainable fashion

Project lead: Algreen Limited

Theme: environmental solutions

P.A.I.N.T.S (production of alternative, innovative and natural-based technologies for styrene)

Project lead: Crown Paints Limited

Theme: clean growth

Machine learning accelerated pathway engineering for sustainable palmitic acid biomanufacture

Project lead: Twig Bio Limited

Theme: clean growth

A bioengineered plant cell biomanufacturing platform for the sustainable production of a natural biopesticide

Project lead: Green Bioactives Limited

Theme: environmental solutions

Apoha: cross-cutting technology to support adoption of synthetic biology food systems

Project lead: Apoha Limited

Theme: food systems

Automation and digitalisation technology for evolutionary development of microbial chassis

Project lead: Evolutor Limited

Theme: crossing cutting tools and services

UPEC SimCell as a potential vaccine against UTI

Project lead: Oxford Simcell Limited

Theme: biomedicine

Optimisation of extracellular lipid production and downstream processing for a palm oil alternative

Project lead: Sun Bear Biofuture

Theme: food systems

TUBERGENE: a pipeline to produce gene edited potatoes to enhance consumer satisfaction

Project lead: B-Hive Innovations Limited

Theme: food systems

NJA-1: a novel synthetic enzyme designed to transform polyolefin recycling

Project lead: Epoch Biodesign Limited

Theme: clean growth

Nylon circular: biocatalysts for recycling of post-consumer nylon

Project lead: Evoralis Limited

Theme: clean growth

Engineering cyanobacteria into bio-solar cell factories for scalable carbon capture utilisation and storage

Project lead: Cyanocapture Limited

Theme: environmental solutions

Intracellular bacterial delivery of therapeutic proteins for treatment of cancer

Project lead: Prokarium Limited

Theme: biomedicine

Development of portable digital cloud-connected biosensor for real-time measurement and mapping of environmental contamination of UK rivers

Project lead: Aquaffirm Limited

Theme: environmental solutions

Yield improvement through synthetic biology for a palm oil alternative from fermentation

Project lead: Sun Bear Biofuture Limited

Theme: food systems

Advancing industrial biotechnology: low-cost and performant microbial polyesters for sustainable packaging

Project lead: Shellworks Group Limited

Theme: clean growth

The RNA desktop biofoundry: end to end platform for RNA R&D, process development and manufacturing

Project lead: Biologic Technologies Limited

Theme: biomedicine

A novel high-throughput scale-out fermentation array for isoprene bioprocess development

Project lead: Twig Bio Limited

Theme: clean growth

Chlorella sorokiniana genetic toolkit for sustainable algae oil production

Project lead: Phycobloom Limited

Theme: clean growth

Towards commercial protein production through co-engineering marine microorganisms and feedstocks for precision fermentation

Project lead: Bravelycultured Limited

Theme: food systems

Biomanufacturing downstream process optimisation and scaling with in-silico experimentation

Project lead: New Wave Biotech Limited

Theme: crossing cutting tools and services

Genomic capture to combat the antimicrobial resistance crisis

Project lead: Bactobio Limited

Theme: biomedicine

Manufacturing scale up of Clickmers, a novel class of therapeutic molecules

Project lead: Apis Assay Technologies Limited

Theme: biomedicine

Device for ultrafast, gold standard amplification and detection of nucleic acids using plasmonic thermocycling: accelerating genomics research and democratising gold-standard disease detection

Project lead: Rapidx Bio Limited

Theme: crossing cutting tools and services

Building a VAST platform to rapidly engineer novel synthetic gene delivery vectors

Project lead: Deliver Biosciences Limited

Theme: biomedicine

Accelerated, multi-parameter enzyme optimisation for the process scale-up of a novel pharmaceutical biocatalyst

Project lead: Imperagen Limited

Theme: clean growth

TRACE (tracking and recording accurate cellular engineering): ensuring provenance in machine learning-driven yeast optimisation

Project lead: Gitlife Biotech Limited

Theme: crossing cutting tools and services

Harnessing the power of engineering biology to develop and translate novel live biotherapeutics

Project lead: NCIMB Limited

Theme: crossing cutting tools and services

Guided Biotics® for control of clostridium perfringens in food production

Project lead: Folium Food Science Limited

Theme: food systems

PRIME: protein recombination improvement through multidisciplinary engineering

Project lead: Multus Biotechnology Limited

Theme: food systems

Optimisation of CAS-based rapid microbial biosensor

Project lead: CEXAL Limited

Theme: environmental solutions

Microbial-derived solutions for enhanced crop protection through synthetic microbial communities

Project lead: Bugbiome Limited

Theme: environmental solutions

Engineering synthetic polymer hydrogels for controlled delivery of extracellular vesicles as an advanced wound care therapy

Project lead: Evolution Therapeutics Limited

Theme: biomedicine

Non-conventional yeast strain optimisation for industrial protein production using deep learning

Project lead: HERlab Limited

Theme: crossing cutting tools and services

The manufacturing of de novo designed protein fibres

Project lead: Solena Materials Limited

Theme: clean growth

A rapid prototyping device for expression of membrane proteins

Project lead: Nuclera Limited

Theme: crossing cutting tools and services

Development of a Yersinia SimCell vaccine against plague

Project lead: Oxford Simcell Limited

Theme: biomedicine

Development of edible hollow fibre bioreactor for cultivated meat production

Project lead: Kalvotech Limited

Theme: food systems

Engineering of safe and efficient animal stem cell lines for cultivated meat production

Project lead: Quest Meat Limited

Theme: food systems

A new, novel bioreactor to power engineering biology

Project lead: Sterling Bio Machines Limited

Theme: crossing cutting tools and services

Engineering of nature-mimetic sub-micron crystalline protein depots to incorporate high cargo densities

Project lead: Cell Guidance Systems Limited

Theme: biomedicine

Process development and cost-effective manufacture of recombinant hormone for livestock reproduction

Project lead: Biodivide Limited

Theme: food systems

About UKRI Technology Missions Fund

The UKRI Technology Missions Fund is designed to exploit the UK’s global leadership in transformative technologies to help solve specific problems, while also helping cement that leading position.

Overall, UKRI is investing £250 million in Technology Missions to enable new and existing capabilities and capacity in artificial intelligence, quantum technologies and engineering biology in the years 2023 to 2025 and beyond. With a further £70 million announced to support future telecommunications.

About the national vision for engineering biology

The national vision for engineering biology published in December 2023 defines the UK government’s collective ambition for engineering biology and sets the direction in which government investment, policy and regulatory reform will deliver through the strands of the Science and Technology Framework.

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