Author: Diego E. Rincon-Limas, Associate Professor of Neurology, University of Florida

Infectious or chronic diseases such as long COVID, Alzheimer’s disease and traumatic brain injury can cause inflammation in the brain, or neuroinflammation, that weakens muscles. While scientists are aware of this link between inflammation and muscle weakness, the molecules and processes involved have been unclear. In our research, our team of neuroscientists and biologists uncovered the hidden conversation between the brain and muscles that triggers muscle fatigue, and potential ways to treat it. Neuroinflammation and muscle fatigue Neuroinflammation results when your central nervous system – the brain and spine – activates its own immune system to protect itself against infection,…